Rome, 1944: The Germans have declared Rome an "open city". Giorgio Manfredi, one of the leaders of the Resistance, is tracked down by the Nazis. He goes to his friend Francesco's, and asks Pina, Francesco's fiancée, for help.
Pina agrees to help him thus risking not only her own life, but also that of her unborn child. She must warn a priest, Don Pietro Pellegrini, who aids the anti-Nazi cause. Giorgio who is an outspoken communist needs to leave the town as soon as possible.